The Role of the COMT Val(158)Met Polymorphism in the Phenotypic Expression of Obsessive-Compulsive Disorder (2024)

Katerberg, H., Cath, D. C., Denys, D. A. J. P., Heutink, P., Polman, A., van Nieuwerburgh, F. C. W., Deforce, D. L. D., Bochdanovits, Z., van Balkom, A. J. L. M. (2010). The Role of the COMT Val(158)Met Polymorphism in the Phenotypic Expression of Obsessive-Compulsive Disorder. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 153B(1), 167-176. https://doi.org/10.1002/ajmg.b.30971

Katerberg, Hilga ; Cath, Danielle C. ; Denys, Damiaan A. J. P. et al. / The Role of the COMT Val(158)Met Polymorphism in the Phenotypic Expression of Obsessive-Compulsive Disorder. In: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 2010 ; Vol. 153B, No. 1. pp. 167-176.

@article{9aa397fda19c47a3bb99d8f8c2a73a9f,

title = "The Role of the COMT Val(158)Met Polymorphism in the Phenotypic Expression of Obsessive-Compulsive Disorder",

abstract = "Obsessive-Compulsive Disorder (OCD) is characterized by the presence of obsessions and compulsions, and shows considerable phenotypic variability. Family and twin studies have indicated a genetic component in the etiology of OCD, and the catechol-O-methyl transferase (COMT) gene is an important candidate gene for OCD. This study investigates the influence of the functional COMT Val158Met polymorphism on the phenotypic expression of OCD, using an item-level factor-analytic approach in a large sample. The COMT Val158Met variant was genotyped in 373 patients and 462 controls. It was tested whether there was an association between the COMT Val158Met polymorphism and OCD or dimensional phenotypes such as YBOCS severity score, age of onset of obsessive-compulsive symptoms and six symptom dimensions recently found in a large item-level factor-analytic study [Katerberg et al., submitted]. We further investigated possible sex-specific associations between the COMT Val158Met polymorphism and OCD or dimensional phenotypes. There was a trend for an association of the COMT 158Met allele with OCD in males, and an interaction between the COMT Val158Met genotype and sex on the somatic and sensory phenomena symptom dimension, with females showing lower scores. In conclusion, a dimensional approach seems fruitful in detecting genes of importance for OCD. (C) 2009 Wiley-Liss, Inc.",

keywords = "OCD, COMT, OC symptom dimensions, age of onset, OC symptom severity, O-METHYLTRANSFERASE COMT, INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW, SYMPTOM DIMENSIONS, EARLY-ONSET, ANXIETY DISORDERS, DSM-IV, ASSOCIATION, GENE, LINKAGE, SUSCEPTIBILITY",

author = "Hilga Katerberg and Cath, {Danielle C.} and Denys, {Damiaan A. J. P.} and Peter Heutink and Annemiek Polman and {van Nieuwerburgh}, {Filip C. W.} and Deforce, {Dieter L. D.} and Zoltan Bochdanovits and {van Balkom}, {Anton J. L. M.} and {den Boer}, {Johan A.}",

year = "2010",

month = jan,

doi = "10.1002/ajmg.b.30971",

language = "English",

volume = "153B",

pages = "167--176",

journal = "American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics",

issn = "1552-4841",

publisher = "Wiley",

number = "1",

}

Katerberg, H, Cath, DC, Denys, DAJP, Heutink, P, Polman, A, van Nieuwerburgh, FCW, Deforce, DLD, Bochdanovits, Z, van Balkom, AJLM 2010, 'The Role of the COMT Val(158)Met Polymorphism in the Phenotypic Expression of Obsessive-Compulsive Disorder', American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, vol. 153B, no. 1, pp. 167-176. https://doi.org/10.1002/ajmg.b.30971

The Role of the COMT Val(158)Met Polymorphism in the Phenotypic Expression of Obsessive-Compulsive Disorder. / Katerberg, Hilga; Cath, Danielle C.; Denys, Damiaan A. J. P. et al.
In: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, Vol. 153B, No. 1, 01.2010, p. 167-176.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The Role of the COMT Val(158)Met Polymorphism in the Phenotypic Expression of Obsessive-Compulsive Disorder

AU - Katerberg, Hilga

AU - Cath, Danielle C.

AU - Denys, Damiaan A. J. P.

AU - Heutink, Peter

AU - Polman, Annemiek

AU - van Nieuwerburgh, Filip C. W.

AU - Deforce, Dieter L. D.

AU - Bochdanovits, Zoltan

AU - van Balkom, Anton J. L. M.

AU - den Boer, Johan A.

PY - 2010/1

Y1 - 2010/1

N2 - Obsessive-Compulsive Disorder (OCD) is characterized by the presence of obsessions and compulsions, and shows considerable phenotypic variability. Family and twin studies have indicated a genetic component in the etiology of OCD, and the catechol-O-methyl transferase (COMT) gene is an important candidate gene for OCD. This study investigates the influence of the functional COMT Val158Met polymorphism on the phenotypic expression of OCD, using an item-level factor-analytic approach in a large sample. The COMT Val158Met variant was genotyped in 373 patients and 462 controls. It was tested whether there was an association between the COMT Val158Met polymorphism and OCD or dimensional phenotypes such as YBOCS severity score, age of onset of obsessive-compulsive symptoms and six symptom dimensions recently found in a large item-level factor-analytic study [Katerberg et al., submitted]. We further investigated possible sex-specific associations between the COMT Val158Met polymorphism and OCD or dimensional phenotypes. There was a trend for an association of the COMT 158Met allele with OCD in males, and an interaction between the COMT Val158Met genotype and sex on the somatic and sensory phenomena symptom dimension, with females showing lower scores. In conclusion, a dimensional approach seems fruitful in detecting genes of importance for OCD. (C) 2009 Wiley-Liss, Inc.

AB - Obsessive-Compulsive Disorder (OCD) is characterized by the presence of obsessions and compulsions, and shows considerable phenotypic variability. Family and twin studies have indicated a genetic component in the etiology of OCD, and the catechol-O-methyl transferase (COMT) gene is an important candidate gene for OCD. This study investigates the influence of the functional COMT Val158Met polymorphism on the phenotypic expression of OCD, using an item-level factor-analytic approach in a large sample. The COMT Val158Met variant was genotyped in 373 patients and 462 controls. It was tested whether there was an association between the COMT Val158Met polymorphism and OCD or dimensional phenotypes such as YBOCS severity score, age of onset of obsessive-compulsive symptoms and six symptom dimensions recently found in a large item-level factor-analytic study [Katerberg et al., submitted]. We further investigated possible sex-specific associations between the COMT Val158Met polymorphism and OCD or dimensional phenotypes. There was a trend for an association of the COMT 158Met allele with OCD in males, and an interaction between the COMT Val158Met genotype and sex on the somatic and sensory phenomena symptom dimension, with females showing lower scores. In conclusion, a dimensional approach seems fruitful in detecting genes of importance for OCD. (C) 2009 Wiley-Liss, Inc.

KW - OCD

KW - COMT

KW - OC symptom dimensions

KW - age of onset

KW - OC symptom severity

KW - O-METHYLTRANSFERASE COMT

KW - INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW

KW - SYMPTOM DIMENSIONS

KW - EARLY-ONSET

KW - ANXIETY DISORDERS

KW - DSM-IV

KW - ASSOCIATION

KW - GENE

KW - LINKAGE

KW - SUSCEPTIBILITY

U2 - 10.1002/ajmg.b.30971

DO - 10.1002/ajmg.b.30971

M3 - Article

SN - 1552-4841

VL - 153B

SP - 167

EP - 176

JO - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

IS - 1

ER -

Katerberg H, Cath DC, Denys DAJP, Heutink P, Polman A, van Nieuwerburgh FCW et al. The Role of the COMT Val(158)Met Polymorphism in the Phenotypic Expression of Obsessive-Compulsive Disorder. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 2010 Jan;153B(1):167-176. doi: 10.1002/ajmg.b.30971